Many of today's advanced building control systems are designed to improve granularity of control for energy efficiency. Examples include direct digital controls for building heating, ventilation, and cooling systems (HVAC), and dimmable ballasts for continuous dimming for daylighting applications. This paper discusses recent research on the use of new and existing controls in commercial buildings for integrated energy efficiency and demand response (DR). The paper discusses the use of DR controls strategies in commercial buildings and provides specific details on DR control strategy design concepts for a new building in New York. We present preliminary results from EnergyPlus simulations of the DR strategies at the New York Times Headquarters building currently under construction. The DR strategies at the Times building involve unique state of the art systems with dimmable ballasts, movable shades on the glass facade, and underfloor air HVAC. The simulation efforts at this building are novel, with an innovative building owner considering DR and future DR program participation strategies during the design phase. This paper also discusses commissioning plans for the DR strategies. The trends in integration of various systems through the EMCS, master versus supervisory controls and dynamic operational modes concepts are presented and future research directions are outlined.