Benzo(C)fluorine, PAH with possible human health implications. (To BAP or not to BAP)

November 7, 2000 - 12:00pm

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental contaminants with potential health consequences. Essentially all the cancer risk from exposure to coal tar, cigarette smoke and other products of incomplete combustion is thought to reflect the contributions of PAHs with 4 or more fused rings. In risk assessment as currently practiced the major contributor to overall risk is the 5-ring PAH benzo(a)pyrene (B(a)P).However, recent studies using a lifetime feeding protocol indicate that B(a)P does not meet criteria for application to risk assessment since it does not induce lung tumors, the endpoint upon which risk assessments should be based. It is important to identify the chemical primarily responsible for lung tumor induction in order to establish risk of PAH. We have recently discovered that a 4-ring PAH, 7H-benzo(c)fluorene, induces damage to lung DNA consistent with tumor induction. Evidence supporting a role for 7H-benzo(c)fluorene in assessing PAH risk will be presented.

Add event to Google Calendar

Announcement List

To be added to our seminar annoucement list please, email ETA Seminars. Seminars may change without notice, stay informed by joining our seminar email list. 

Site Access

For site access please email your request to ETA Seminars. To arrive at Building 90 via the LBNL shuttle, take "Blue Uphill". Click here for the shuttle schedule. To ensure your site access is set-up send your request 36 hours in advance of the seminar.

Remote Access

Not able to attend in person? Remote participants can use ReadyTalk Audio & Net conference to phone in to listen, while viewing the presentation via the ReadyTalk site.

Web Access Code: 4864835

USA & Canada call-in number:
1 (866) 740-1260
Access Code: 4864835#

International callers:
Please visit this website to see if a toll-free call-in number is available for your international location.

If not, you will need to pay for the call yourself and use this phone number:

(303) 248-0285.